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Question: Onc

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Which of the following is a lab finding in tumor lysis syndrome?
LabsOncology

pemsou5_wp • November 28, 2023


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  1. Kelly November 30, 2023 - 9:16 pm Reply

    D) Hyperuricemia
    Tumor lysis syndrome is an oncologic emergency, most commonly seen after initiating chemotherapy, particularly in a patient with newly diagnosed leukemia and a very high WBC count and in high grade / advanced lymphomas. A rapid turnover of tumor cells leads to a massive release of intracellular ions. Findings include: hyperkalemia, hyperphosphatemia, hypocalcemia (due to chelation of phosphorus), hyperuricemia and elevated LDH (due to rapid cell turnover). Treatment for tumor lysis syndrome includes rapid volume expansion, allopurinol or febuxostat (decrease uric acid production), recombinant urate oxidase (rasburicase), urine alkalinization with NaHCO3 to enhance uric acid if rasburicase not immediately available, calcium, hyperkalemia treatment as indicated.

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