PEM Source

Your source for all things Pediatric Emergency Medicine


Question: Tox

(Click the link to comment and to vote – voting not working through email, sorry!)

You are seeing a child with suspected methemoglobinemia from overuse of benzocaine teething gel. You plan to treat with methylene blue. Which of the following past medical history conditions makes methylene blue a contraindicated treatment?

Methylene blue is contraindicated in:

pemsou5_wp • June 4, 2019

Previous Post

Next Post


  1. Kelly June 7, 2019 - 10:46 pm Reply

    B) G6PD deficiency
    Methylene blue helps reduce the oxidized hemoglobin of methemoglobinemia from Fe3+ back to the Fe2+ state. It is contraindicated in those with G6PD deficiency since it can set off hemolysis. It is also contraindicated in Heinz body anemia, in severe renal failure, and in those with a history of hypersensitivity to methylene blue. It may also cause serotonin syndrome when co-administered with serotonergic drugs such as SSRIs.

Leave a Reply

Your email address will not be published / Required fields are marked *