Question: OB-Gyn

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Kelly April 16, 2019 - 4:03 pm Reply

D) Uterine cramping and bleeding is expected within 6 hours of mifepristone administration Medical abortion regimens commonly involve administration of mifepristone 200-600 mg orally, followed in 24-48 hours by misoprostol orally, vaginally, buccally, or sublingually. The FDA approved regimen of mifepristone 600mg orally then misoprostol 400 mcg orally in 48 hours is approved for < 49 days gestation and is 92% successful in that range. It is more successful in younger gestations: 96-98% up to 42 days gestation. Although only approved for up to 49 days, regimens have been used up to 63 days or higher. Mifepristone is more effective than methotrexate and is preferred. Uterine cramping and bleeding generally start 1-4 hours after the misoprostol (or 24-48 hours after mifepristone administration). Nausea, vomiting, headache, and dizziness are other common adverse effects.