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Ibuprofen in infants
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Note: conundrums are not meant to have a “right” answer – they are to see how most people are practicing. Would love your comments also regarding your thought processes and the evidence behind your decisions. We can learn from each other!
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Kelly Young April 30, 2018 - 4:24 am
There are not a lot of data on safety and efficacy of NSAIDs in infants. The concern is that young infants have immature renal function. Ibuprofen is approved for 6 months and older in the US and parts of Europe, but is used in infants aged 3-6 months in the UK and Australia. Ziesenitz VC et al Pediatr Drugs 2017;19:277-290 reviewed available data. They concluded that ibuprofen is safe in infants 3 months and older, weighing at least 5-6 kg, and with a dose of 5-10 mg/kg orally, 3-4 times per day, not to exceed 30-40 mg/kg/day.