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Question: Tox

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You are seeing a child with suspected methemoglobinemia from overuse of benzocaine teething gel. You plan to treat with methylene blue. Which of the following past medical history conditions makes methylene blue a contraindicated treatment?

Methylene blue is contraindicated in:
PharmTox

pemsou5_wp • June 4, 2019


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  1. Kelly June 7, 2019 - 10:46 pm Reply

    B) G6PD deficiency
    Methylene blue helps reduce the oxidized hemoglobin of methemoglobinemia from Fe3+ back to the Fe2+ state. It is contraindicated in those with G6PD deficiency since it can set off hemolysis. It is also contraindicated in Heinz body anemia, in severe renal failure, and in those with a history of hypersensitivity to methylene blue. It may also cause serotonin syndrome when co-administered with serotonergic drugs such as SSRIs.

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